11 Beta Hydroxylase Deficiency

Below you will find more information about 11 Beta Hydroxylase Deficiency from Medigest. If you believe that you are suffering from any of the symptoms of 11 Beta Hydroxylase Deficiency it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with 11 Beta Hydroxylase Deficiency and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to 11 Beta Hydroxylase Deficiency comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


It is important to understand what congenital adrenal hyperplasia (CAH) is before the nature of 11 beta hydroxylase deficiency can be fully explained. CAH refers to any one of the many autosomal recessive illnesses that result from flaws in cortisol synthesis steps done by the adrenal glands. All of the types of CAH have either overproduction or malfunctioning of sex steroids. 11 beta hydroxylase deficiency is just one of the types of CAH and is a result of mutation in the gene called CYP11B1. This type is next only to 21-hydroxylase deficiency when it comes to its prevalence, comprising only 5-8% of the entire number of cases.


The patients who suffer from hypertensive symptoms tend to take up most of the number of deaths.


In the case of salt wasting, an intravenous saline or dextrose could be used to stabilize the patient's condition. Like most cases of CAH, it is necessary to have enough doses of glucocorticoid replacement for the suppression of androgen and mineralocorticoid. Hypertension can also be ameliorated using this method. It is necessary to have balanced dosages as oversuppression could also lead to growth retardation.

Manifestations of the Disease

11 beta hydroxylase deficiency often resembles the primary type of CAH when it comes to its symptoms. The manifestations can be any one of the following: virility of female infants; a baby girl genitalia looking more like a male's because of the enlarged clitoris; boys having pubic hair way before adolescence; some reported cases of irregularities on menstruation; infant salt wasting; body odor among adults; and even some uncommon cases of infertility among adolescent and mature females. Another possible symptom of this deficiency is hypertension. This symptom sets the 11 beta hydroxylase deficiency apart from the 21- hydroxylase deficiency type. About two-thirds of people diagnosed with this deficiency succumb to hypertension. The precise reason why hypertension develops is still undefined but some studies show that over secretion of DOC, which is a mineralcorticoid, could be a triggering factor. The first 26 cases of hypertension due to 11 beta hydroxylase deficiency were observed and reported way back in 1982.


Jewish people who are descendants of Moroccans are more prone to have the illness. There is about 1 in every 5,000 to 7,000 births in Morocco and Israel that shows symptoms of the deficiency. In the United States, the statistics show 1 in every 100,000 births.

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