Acute promyelocytic leukemia

Below you will find more information about Acute promyelocytic leukemia from Medigest. If you believe that you are suffering from any of the symptoms of Acute promyelocytic leukemia it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Acute promyelocytic leukemia and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Acute promyelocytic leukemia comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.

Definition

Acute promyelocytic leukemia (APL) is a known subtype of AML or acute myologenous leukemia, which is a form of cancer of the bone marrow and the blood. APL patients suffer from the abnormal accumulation of underdeveloped granulocytes . APL is characterized as a disorder brought about by chromosomal translocation.

Diagnosis

To be able to properly distinguish APL from other forms of leukemia, a morphologic examination is required through aspirate or bone marrow biopsy. To monitor relapse, doctors use PCR tests for allow early re-treatment.

Treatment

Among many types pf leukemia, APL is quite unique and is known to display sensitivity to ATRA or all-trans retinoic acid, which is a derivative of vitamin A. That is try treatments with ATRA is combined with anthracycline chemotherapy that usually results to remission in about 90% of the APL patients.

Symptoms and Signs

APL shares the common symptoms found in AML. This includes fatigue, fever, loss of appetite, easy bleeding, anemia, bone and joint pains as well as increased susceptibility to infections.

Causes

APL is caused by chromosomal translocations, which is a DNA abnormality that causes leukemia to develop. Normally, the human DNA consists of 23 pairs of chromosomes. In APL, one chromosome breaks off and gets attached to another chromosome, hence the term translocation.

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