Adrenal hyperplasia

Below you will find more information about Adrenal hyperplasia from Medigest. If you believe that you are suffering from any of the symptoms of Adrenal hyperplasia it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Adrenal hyperplasia and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Adrenal hyperplasia comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.

Definition

Congenital adrenal hyperplasia (CAH) generally refers to several autosomal recessive medical conditions that are results from some biochemical pathway of the steroidogenesis of the cortisol from cholesterol by the patient's adrenal glands. Majority of these conditions involve lesser or greater production of sex steroids and can also greatly alter the development of primary and secondary sex characteristics in affected individuals.

Diagnosis

Among the most prominent clinical clues include the patient's abnormal weight loss, and signs of electrolyte abnormalities

Treatment

For infants born with ambiguous genitalia are required to be closely observed for any symptoms of salt wasting while a diagnosis is being established. For patients suffering from dehydration and hyponatremia should receive intravenous fluid containing isotonic sodium chloride

Symptoms and Signs

Patients displaying non-sever symptoms include normal genitalia at birth, although clitoromegaly and pubic hair tend to appear in early childhood. Other indicators include high blood pressure and hypokalemia.

Causes

The particular defects that cause the congenital adrenal hyperplasia include the autosomal recessive disorders that may be due to deficient activity of a protein that is involved in cortisol and aldosterone. In majority of the cases, CAH is mainly due to a deletion or mutation of the particular gene that codes for the protein.

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