Anemia, Pernicious

Below you will find more information about Anemia, Pernicious from Medigest. If you believe that you are suffering from any of the symptoms of Anemia, Pernicious it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Anemia, Pernicious and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Anemia, Pernicious comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


Pernicious anemia, also called "Addisson's anemia" or "Biermer's anaemia", is a type of megalobastic anemia caused by vitamin B12 deficiency. This condition is the most common cause of vitamin B12 deficiency in adults.


Diagnosis of Pernicious anemia requires a full blood count and measurements of 12 levels in serum. To distinguish Pernicious anemia from other diseases that cause vitamin B12 deficiency, a Schillings test is recommended.


Since this condition manifests vitamin B12 deficiency, Pernicious anemia is treated by administering sufficient amounts of vitamin B12 through supplementation. Oral tablets are available; however, higher doses are usually given to Pernicious anemia patients. Vitamin B12 can also be administered through injection, which is normally given once a month to counter the deficiency.

Symptoms and Signs

Symptoms of Pernicious anemia include anemia and anemia-related conditions such as shortness of breath, fatigue and pallor. It also causes tongue symptoms, including soreness, redness and burning of tongue. Patients of Pernicious anemia also experience loss of appetite, diarrhea, weight loss, constipation, abdominal pain, fever, unsteadiness, muscle spasms, fever, malaise, spasticity, weakness, jaundice, upset stomach, chest pain and rapid heartbeat. Other patients of Pernicious anemia experience megaloblastic anemia, movement disorders, personality changes and finger paresthesias (or burning sensations in fingers).


In temperate climates, impaired binding of vitamin B12 are caused by an intrinsic factor called autoimmune atrophic gastritis, wherein autoantibodies are autoantibodies are directed against the parietal cells, resulting the loss of vitamin B12. This condition also directs autoantibodies against intrinsic factor itself, making it unable to bind vitamin B12.

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