Anemia, Sideroblastic

Below you will find more information about Anemia, Sideroblastic from Medigest. If you believe that you are suffering from any of the symptoms of Anemia, Sideroblastic it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Anemia, Sideroblastic and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Anemia, Sideroblastic comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.

Definition

Sideroblastic anemia is a condition caused by the abnormal production of red blood cells, normally as a part of myelodysplastic syndrome that can evolve into hematological malignancies, such as acute myelogenous leukemia. When this happens, the patient's body will have iron, but it cannot incorporate this into the hemoglobin.

Diagnosis

To diagnose Sideroblastic anemia, ringed "sideroblasts" should be present in the bone marrow. Anemia is usually moderate to severe with marked poikilocytosis and anisocytosis. In the lab findings, patients with Sideroblastic anemia have an increased level of ferritin, decreased iron-binding capacity, 20% to 30% hematocrit, high serum iron levels, high transferring saturation, lead poisoning, slightly increased mean corpuscular volume.

Treatment

Sideroblastic anemia usually causes severe symptoms. As such, transfusion is often required, especially to patients that do not respond to "erythropoietin therapy".

Causes

The most common cause of Sideroblastic anemia is failure to form "heme" completely. The biosynthesis of this "heme" takes place in the mitochondrion, leading to the abnormal deposits of iron in the mitochondria that forms a ring around the developing red blood cells. Sometimes, Sideroblastic anemia represents a type of generalized bone marrow disorder, which ultimately lead to acute leukemia. Causes of Sideroblastic anemia include toxins, such as zinc or lead poisoning, copper and pyridoxine deficiency, ALA synthase deficiency and drug-induced clycloserine, isoniazid, ethanol and chloramphenicol.

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