Anterior horn disease

Below you will find more information about Anterior horn disease from Medigest. If you believe that you are suffering from any of the symptoms of Anterior horn disease it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Anterior horn disease and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Anterior horn disease comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


Anterior horn disease is a condition that affects the anterior horn cells, which are responsible for voluntary muscle activities, such as breathing, walking, swallowing and speaking. Anterior horn disease is characterized by the death of more neurons, which result in a prolonged and progressive motor weakness. Some patients with anterior horn disease are affected permanently.


There is no cure for Anterior horn disease. The only medicine used for Anterior horn disease patients is "riluzole".

Symptoms and Signs

Anterior horn disease presents symptoms associated with the lower and upper motor neurone degeneration, such as brisk reflexes, spasticity, Babinski sign (for lower motor neurone), weakness and muscle atrophy (for upper motor neurone). Note that all muscle groups in the human body require both lower and upper motor neurones in order to function. These signs could occur in various muscle groups, including the torso, legs, arms and the bulbar region. Symptoms of Anterior horn disease usually appear in ages of 50 to 70. Symptoms include muscle wasting, progressive weakness, muscle fasciculations, arms and legs spasticity, stiffness and overactive reflexes of tendons. Other patients experience serious symptoms such as slurred speech, dragging foot or unilateral muscle wasting of the hands.


Anterior horn disease has no known cause. However, genetic factors are important in determining a person's vulnerability to this disease.

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