Antiphospholipid syndrome

Below you will find more information about Antiphospholipid syndrome from Medigest. If you believe that you are suffering from any of the symptoms of Antiphospholipid syndrome it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Antiphospholipid syndrome and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Antiphospholipid syndrome comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


Antiphospholipid syndrome, simply called "APLS" or "APS", is a disorder of coagulation, which causes pregnancy-related complications such as preeclampsia, miscarriage and preterm deliver. It also causes blood clots in both veins and arteries. The syndrome occurs because of the production of antibodies against phosphilipids. This disorder is characterized by antibodies against B2 glycoprotein I and cardiolipin. Antiphospholipid syndrome is usually seen in conjunction with other autoimmune-related diseases. In some cases, Antiphospholipid syndrome can lead to high risk of death and dramatic organ failure caused by generalized thrombosis.


Antiphospholipid syndrome is treated by administering aspirin to inhibit the platelet activation. Some doctors recommend warfarin as anti-coagulant. Pregnant patients of APS require low-dose aspirin and low molecular weight heparin. Women with recurrent miscarriages are usually advised to take aspirin after missing a menstrual period.

Symptoms and Signs

Antiphospholipid syndrome could cause blood clots in any organ and pregnancy related complication in the second or third trimester. In Antiphospholipid syndrome patients, the most common symptom is deep vein thrombosis of the lower extremities. Stroke is the most common arterial event. Some patients with Antiphospholipid syndrome experience migraines and headaches. Most APS patients experience low platelet count, livedo reticularis and heart valve disease. In 10% of Antiphospholipid syndrome patients, symptoms of multiple sclerosis may be present.

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