Autoimmune polyendocrinopathy syndrome, type I

Below you will find more information about Autoimmune polyendocrinopathy syndrome, type I from Medigest. If you believe that you are suffering from any of the symptoms of Autoimmune polyendocrinopathy syndrome, type I it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Autoimmune polyendocrinopathy syndrome, type I and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Autoimmune polyendocrinopathy syndrome, type I comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.

Definition

Autoimmune polyendocrinopathy syndrome, type I is a very unusual autoimmune disorder distinguished by autoimmune polyendocrinopathy (APE), candidiasis (C) and ectodermal dysplasia (ED). Theh disorder is also called as candidiasis-hypoparathyroidism-Addison's disease-syndrome following its major features: * Mild immune deficiency that leads to mucosal and cutaneous infections alog with candida yeasts. The function of the spleen is also reduced or referred to as asplenism. * Parathyroid gland's autoimmune dysfunction that leads to hypocalcemia and the adrenal gland. Other ailments that are related: hypothyroidism hypogonadism and infertility vitiligo (depigmentation of the skin) alopecia (baldness) malabsorption pernicious anemia chronic active (autoimmune) hepatitis In contrast to type 2, this type takes over an autosomal recesive style and it is because of a defect in AIRE or autoimmune regulator a gene that is seen on the 21st chromosomes. A transcription factor, normal function AIRE exhibits to display immune lenience for antigens from endocrine organs.

Symptoms and Signs

Blood calcium level is low Blood phosphate level is low Hypoparathyroidism Lack/absence of tooth enamel Hair loss Piece of de-pigmented skin Corneal dystropathy Sexual growth fails Yeast infection in mouth Yeast infection in nails Mal-absorption Disease in the liver Insulin-dependent diabetes

Complications

Autoantibodies Immune deficiency Adrenal cortex insufficiency Malabsorption syndrome

Discuss Autoimmune polyendocrinopathy syndrome, type I in our forums

Discuss Autoimmune polyendocrinopathy syndrome, type I with other members of Medigest in our forums.