Castleman’s Disease

Below you will find more information about Castleman’s Disease from Medigest. If you believe that you are suffering from any of the symptoms of Castleman’s Disease it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Castleman’s Disease and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Castleman’s Disease comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


Castleman's disease is considered an uncommon illness affecting the lymph nodes and the body's immune-cell structures. The disease is categorized as lymphoproliferative disorder; meaning it involves overgrowth or proliferation of the lymphatic cells. While it's similar to lymphatic system cancers in many ways, Castleman's disease is non-cancerous. It has two types: Unicentric that involves one site of tissue growths, and Multicentric involving multiple sites of growths.


Castleman's disease can be diagnosed through several tests, although the unicentric type is frequently found incidentally. Tests that doctors can conduct to diagnose the disease include physical examination, imaging techniques, urine and blood tests, and lymph node biopsy.


Treatment will mainly depend on the disease type a patient has. The unicentric type is almost always treated with surgery, while the multicentric type requires more methodical therapies.

Symptoms and Signs

The symptoms an individual will experience depend on the type of Castleman's disease they have. Every person with the disease develops one tumor or more in the body's lymph node tissue. Depending on the type, tumors can develop in areas of the chest, neck, or stomach, as well as experience weight loss, skin rash, fever, and enlarged spleen and liver.


Physicians are still determining the disease's exact cause, but many believe that it is due to an infection of a virus called HHV8 or Human Herpes Virus 8. Another probable contributor might be a protein type produced by the immune cells known as IL-6.

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