Cinchonism

Below you will find more information about Cinchonism from Medigest. If you believe that you are suffering from any of the symptoms of Cinchonism it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Cinchonism and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Cinchonism comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.

Definition

Cinchonism is defined as a pathological disorder involving a prolonged or excessive use of a white-crystalline alkloid component called quinine, or its natural supplier -the cinchona bark. Quinine is primarily used for treating resistant malaria, night-time muscle cramps, as well as can act as an "abortifacient". It can harmfully affect nearly all body system, the most common being cinchonism or quinine poisoning.

Diagnosis

The disorder is diagnosed through blood test for blood sugar, blood count, renal function tests, urinalysis, prothrombin time, and electrolytes. Periodic examinations of the eyes must have visual acuity test. Other methods for diagnosis include electrooculogram, color testing, and dark adaptations.

Treatment

Most symptoms can be reversed and resolved through discontinuing the use of quinine. Mild symptoms typically resolve promptly; however, severe symptoms may persist for several months. Quinine is quickly absorbed, so any attempts to take out quinine in the stomach through gastric lavage might not be effectual. Multiple-dose of activated charcoal has shown to reduce concentrations of plasma quinine.

Symptoms and Signs

Mild cinchonism symptoms include vasodilation, headache, sweating, tinnitus, nausea, dizziness, hearing impairment, color perception disturbance, and blurred vision. More severe manifestations include diarrhea, vomiting, deafness, abdominal pain, blindness, and cardiac rhythm disturbances.

Causes

The main cause is quinine overdose.

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