Corticobasal degeneration

Below you will find more information about Corticobasal degeneration from Medigest. If you believe that you are suffering from any of the symptoms of Corticobasal degeneration it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Corticobasal degeneration and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Corticobasal degeneration comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


Corticobasal degeneration (CBD) is an incurable neurological disorder that manifests itself through muscle rigidity and speech problems. Symptoms usually begin surfacing when patients reach 60 years old, affecting one side of the body and eventually progressing to both sides in 6 to 8 years. It may affect speech first before interfering with muscle movement.


An autopsy will conclusively determine the occurence of CBD. It will indicate that the brain tissue of the CBD patients is characterized by nerve cell loss, gliosis and atrophy (shrinkage) of the posterior frontal and/or parietal lobes and substantia nigra. Swollen nerve cells that contain neurofilament, and inclusions similar to those seen in Pick's disease, may be observed, as well.


There is no cure and no treatment to slow down the progression of this condition. Symptoms do not respond to therapy, while medication treating the Parkinson's disease-like symptoms are observed to have no significant and long-term effect.

Symptoms and Signs

There are three key symptoms observed among CBD patients, namely, alien hand syndrome (the inability to recognize one's hand as part of his body and lack of hand movement control), apaxia (inability to move body purposely) and trouble with spatial orientation showing through the difficulty in using utensils or dressing, and acalculia (difficulty in carrying mathematical calculations such as addition and subtraction). There are also Parkinson's disease-like symptoms associated with CBD including poor coordination, akinesia (absence of movements), rigidity, impaired balance, and dysphagia (difficulty in swallowing). Another sign of the disease is speech problem.


Recent research shows that this condition is caused by cells that contain abnormal form of protein tau. In most cases, it is not genetic.

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