Cowden’s disease

Below you will find more information about Cowden’s disease from Medigest. If you believe that you are suffering from any of the symptoms of Cowden’s disease it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Cowden’s disease and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Cowden’s disease comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


The genetic disorder Cowden's disease causes the tumor-like growths called hamartomas to develop on one's skin or mucous membranes. Noncancerous and small, this may also grow in various areas of the body including the intestinal tract. Patients with Cowden syndrome are much more likely to contact uterus cancer, breast cancer, and thyroid cancer.


This disease is hard to diagnose; it occurs in 1 in 200,000 people.


Managing Cowden's syndrome rests primarily on the early detection, such that patients should undergo periodic mammograms, thyroid scans, laboratory tests, among others.

Symptoms and Signs

Aside from growth of hamartomas, individuals afflicted with this disease have larger head. They may also be sick with Lhermitte-Duclos disease, a benign brain tumore, and mental retardation.


Most cases of Cowden syndrome (around 80 percent) is caused when the gene that suppresses tumors, PTEN, mutate. As such, PTEN controls the cell development and division. With it mutates, PTEN is unable to direct the survival and the division of the cells. The remaining cases of Cowden syndrome is caused by unknown factors.

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