Creutzfeldt-Jakob disease

Below you will find more information about Creutzfeldt-Jakob disease from Medigest. If you believe that you are suffering from any of the symptoms of Creutzfeldt-Jakob disease it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Creutzfeldt-Jakob disease and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Creutzfeldt-Jakob disease comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


The fatal and rare denerative brain disease Creutzfeldt-Jakob disease (CJD) is caused by proteins called prions that multiply exponentially by refolding native proteins to infected state. Disrupting cell function, CJD results to cell death, rapid and progressive dementia, loss of memory, hallucinations and behavioral changes. Death can occur in as little as four months after the onset of the first symptoms.


Individuals exhibiting symptoms of CJD need to undergo electoencephalography, celebrospinal fluid for 14-3-3 protein, and MRI of the brain for conclusive diagnosis.


Search for CJD's cure continues. Experimental treatment of the medication called pentosa polysulphate, which is used in treating interstitial cystitis, slowed the progression of the disease. No sufficient data however suggests that this would be an effective treatment.

Symptoms and Signs

CJD first affects the mental capacity of patients, causing behavioral changes, memory loss, among other cognitive problems. Physical problems will likewise surface impairing speech, balance and coordination, and movements.


The gene mutations of prion protein is the mechanism that causes the dominant alpha helical regions to misfold and turn to beta pleated sheets, disabling the protein's ability for digestion. Infected prion are believed to come from human growth hormone products, electrode implants and, corneal and dural grafts. It may be inherited or transmitted by consuming meat affected with the disease's bovine form.

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