Cronkhite-Canada disease

Below you will find more information about Cronkhite-Canada disease from Medigest. If you believe that you are suffering from any of the symptoms of Cronkhite-Canada disease it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Cronkhite-Canada disease and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Cronkhite-Canada disease comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


The rare syndrome Cronkhite-Canada is a disorder prevalent among individuals 50 to 60 years old and characterized by the presence of multiple polyps in our digestive tract. The polyps affect the large intestine, stomach, small intestine and esophagus, causing gastrointestinal disturbances, malnutrition, malabsorption and even colorectal cancer. The polyps are hamartomas, growths which are often non-cancerous.


These tests are needed to rule out other diseases as the causes of the symptoms - baseline blood test and erythrocyte sedimentation rate. Patients with Cronkhite-Canada have to continuously undergo laboratory examinations to monitor the progress of the disease.


A combination of intensive treatments, which may include medications, surgery and changes in diet, are necessary in managing the disease and its complications effectively. Replacing fluids, electrolytes along with meeting required nutrients are helpful. Systemic infections may be remedied by antibiotics. Surgery is advisable to address complications such as malignancy, bleeding ulcers, intussusception, and perforation.

Symptoms and Signs

Many patients suffering from Cronkhite-Canada will experience changes in skin pigmentation, diarrhea, alopecia, hair and nail loss and profound malnutrition. The disease progresses over time, with the nutritional symptoms eventually leading to situations such as edema and alarming loss of weight.


Research has not shed some light into what causes this syndrome. What is known is that Cronkhite-Canada is not hereditary and that it largely affects Japanese more than any race. Two-thirds of reported cases came from the country, with male to female patient ratio at 2:1.

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