Crow-Fukase Syndrome

Below you will find more information about Crow-Fukase Syndrome from Medigest. If you believe that you are suffering from any of the symptoms of Crow-Fukase Syndrome it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Crow-Fukase Syndrome and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Crow-Fukase Syndrome comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


The rare medical condition called Crow-Fukase syndrome is also called POEMS syndrome after the clinical features that distinguish it from other diseases - Polyneuropathy (peripheral nerve damage), Organomegaly (abnormal enlargement of organs), Endocrinopathy (damage to hormone-producing glands)/Edema, M-protein (an abnormal antibody) and Skin abnormalities (including hyperpigmentation and hypertrichosis).


A battery of tests are performed in the diagnosis of Crow-Fukase syndrome including bone marrow biopsy, lymph node biopsy, electromyography and nerve biopsies.


The scientific community has not proven a therapy or medication to have effectively managed or treated the disease.

Symptoms and Signs

The effects of Crow-Fukase syndrome is far-reaching, with symptoms divided into major and minor criteria. Major signs are polyneuropathy and monoclonal plasmaproliferative disorder. Minor symptoms are sclerotic bone lesions, endocrinopathy, Castleman disease, edema, skin changes, and orgamegaly. Patients will also suffer from pulmonary hypertension, fever, diarrhea, low vitamin B12, weight loss, among other symptoms.


There is no known cause of Crow-Fukase syndrome, though it is believed that paraprotein as well as the vascular endothelial growth factor maybe responsible for the development of the disease.

Discuss Crow-Fukase Syndrome in our forums

Discuss Crow-Fukase Syndrome with other members of Medigest in our forums.