Below you will find more information about Cryoglobulinemia from Medigest. If you believe that you are suffering from any of the symptoms of Cryoglobulinemia it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Cryoglobulinemia and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Cryoglobulinemia comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


The precipitation of the proteins called cryoglobulins in low temperature can cause serious health problems for some people. The condition is called cryoglobulinemia and it occurs when there are huge deposits of cryoglobuline in the blood, damaging organs and causing illness. It could be linked to multiple myeloma, liver disease, lymphoma, and infection. More women are afflicted with the disease.


Extensive laboratory exams will determine the existence of the disease, such as complete blood count, complement assay, liver function test, rheumatoid factor, cryoglobulin test, urinalysis, angiogram, hepatitis-C exam, chest X-ray, protein electrophoresis-serum and ESR.


Managing cryoglobulinemia disease involves careful monitoring and therapy. Medications like prednisone, chemotherapy, and anti-inflammatory drugs are administered to manage the symptoms. In severe complications, plasmapheresis, a treatment that reduces the cryoglobulins levels, is undertaken. Patients may also avoid going to cold areas to prevent certain symptoms.

Symptoms and Signs

Patients will experience different symptoms depending on the organs affected by cryoglobulinemia. These are some of the signs: fatigue, joint pain, skin death, Raynaud's phenomenon, muscle pain, skin ulceration, enlarged liver and spleen, and purpura.


It is not known how an individual acquires cryoglobulinemia, but this non-genetic disorder is linked to certain diseases and the hepatitis C virus.

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