Primary Lateral Sclerosis

Below you will find more information about Primary Lateral Sclerosis from Medigest. If you believe that you are suffering from any of the symptoms of Primary Lateral Sclerosis it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Primary Lateral Sclerosis and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Primary Lateral Sclerosis comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


Primary lateral sclerosis is a progressive degenerative characterized by progressive muscle weakness present in the voluntary muscles. The disease belongs to the category of motor neuron diseases; which usually develops when nerve cells responsible for voluntary muscle movement degenerate and die.


Careful clinical examination is performed by a qualified health professional to rule out other conditions presenting the same symptoms. Complete neurological examination can be helpful in providing diagnosis of primary lateral sclerosis. Magnetic Resonance Imaging of the brain and spine can provide a more detailed presentation of both areas to find out evidence causing spasticity of the muscles.


There is no treatment that can cure, prevent, stop, or set back primary lateral sclerosis. Treatment is usually aimed at relieving the symptoms including medications to lessen uncontrolled muscle spasms; physical therapy and essential exercise routines to preserve and encourage flexibility and strength; improve function by means of assistive devices and other modalities used in physical therapy.

Symptoms and Signs

Symptoms suggesting primary lateral sclerosis include difficulty in maintaining balance leading to clumsiness due to stiffness or weakness in the legs, sudden and uncontrolled muscle spasm and twinges in the extremities, and foot dragging. Speech difficulties may also occur when the facial muscles are involved.


Primary lateral sclerosis is caused by degeneration and eventually death of the upper motor neurons present in the brain and spinal cord, which causes weakness of voluntary muscles.

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