Below you will find more information about Primary Sclerosing Cholangitis from Medigest. If you believe that you are suffering from any of the symptoms of Primary Sclerosing Cholangitis it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Primary Sclerosing Cholangitis and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Primary Sclerosing Cholangitis comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.
Primary sclerosing cholangitis is a medical condition characterized by inflammation and scarring of the bile ducts located inside and outside the liver, which causes bile duct blockage, bile accumulation in the liver resulting to damaged liver cells and eventually lead to liver failure.
Physical symptoms and liver function test results showing extremely elevated blood levels of liver enzymes may suggest diagnosis of primary sclerosing cholangitis. Endoscopic Retrograde Cholangiopancreatography (ERCP) can provide image showing narrowed bile ducts; this method is considered as the gold standard for diagnosing primary sclerosing cholangitis. Magnetic resonance cholangiography provides image of the liver and bile ducts.
Treatment includes medications like Rifampin to diminish itching; antibiotics to control infection; Ursodiol given orally to restore and replenish other bile acids in the body to delay the progression of the disease. For patients diagnosed with advance cirrhosis, treatment usually requires liver transplantation. Surgery is also required for patients who have developed dominant strictures in the extrahepatic bile ducts.
Symptoms and Signs
Primary sclerosing cholangitis produces symptoms that are associated with itching, fatigue, abdominal pain, and yellowing of the skin and eyes (jaundice). Chills and fever is commonly present when infection has occurred. There are also cases when primary sclerosing cholangitis produces no symptoms and are only discovered due to abnormally elevated alkaline phosphatase levels (a liver enzyme) during a routine physical examination.
The exact cause of primary sclerosing cholangitis is unknown.Discuss Primary Sclerosing Cholangitis in our forums
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