Retroperitoneal Fibrosis

Below you will find more information about Retroperitoneal Fibrosis from Medigest. If you believe that you are suffering from any of the symptoms of Retroperitoneal Fibrosis it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Retroperitoneal Fibrosis and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Retroperitoneal Fibrosis comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


Retroperitoneal fibrosis, also known as Ormond's disease, is a condition in which the fibrous tissue proliferates in the retroperitoneum, or the compartment of the body containing the renal tract, kidneys, aorta, and various other structures.


Retroperitoneal fibrosis can be diagnosed on the basis of a patient's family history as well as through radiologic testing. In some cases, diagnosis of the disease cannot be confirmed until further surgical exploration. Recent advances in research indicate that steroids can be used as an alternative to surgical ureterolysis.


Treatment for retroperitoneal fibrosis is commonly based on administering glucocorticoids, followed by DMARDs. In addition, SERM tamoxifen has also some proven efficacy in research trials, although further studies are needed to determine the mechanism of its action. Immunosuppressive drugs, including cyclophosphamide, azathioprine, and tamoxifen may also be used. However, if afflicted patients exhibit severe urinary tract obstruction, surgical intervention becomes almost always necessary.

Symptoms and Signs

Common symptoms of retroperitoneal fibrosis include renal failure, deep vein thrombosis, lower back pain, hypertension, and a range of other obstructive symptoms.


Retroperitoneal fibrosis is associated with a variety of immune-related conditions. The disease can also develop as a result of immunosuppression, leading to suspicion of an autoimmune etiology. A third of recorded retroperitoneal fibrosis cases are secondary to medication, malignancy, aortic aneurysm, or certain infections.

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