Sezary SYndrome

Below you will find more information about Sezary SYndrome from Medigest. If you believe that you are suffering from any of the symptoms of Sezary SYndrome it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Sezary SYndrome and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Sezary SYndrome comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


Sezary syndrome also referred to as Sezary's disease is a rare type of cutaneous lymphoma characterized by skin redness, leukemia and enlarged lymph nodes. It is a form of cutaneous T-cell lymphoma, which is a cancerous disease involving the skin. This is a disease marked by a great increase of the white blood cells known as T-lymphocytes.


People with lesion that do not response to normal medications are required to undergo a blood test in order to monitor the change in the level of lymphocytes in the blood. After which, a skin biopsy is often ordered to confirm diagnosis and to rule out other possible causes of the lesion.


Early stages of Sezary syndrome might be treated with skin therapy directly on the skin like topical medications, superficial radiotherapy and phototherapy. Chemotherapy and immunotherapy are required treatments for advanced stages of the disease. A medication named Vorinostat is considered as a second-line drug for cutaneous T-cell lymphoma combined with phototherapy and chemotherapy.

Symptoms and Signs

Sezary syndrome usually develops slowly within many years. Initial symptoms usually appear on the skin including skin redness, itching and often dry and dark patches on the skin. Other symptoms may include: ò Leukemia ò Enlarged lymph nodes ò Dystrophic nails ò Hair loss or balding (alopecia) ò Swelling


At present, there is still no known cause for the development of Sezary Syndrome.

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