Syndrome Of Inappropriate Antidiuretic Hormone

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Definition

The syndrome of inappropriate antidiuretic hormone (SIADH) is a condition generally found in the hospital population, especially in patients being hospitalized for central nervous system (CNS) injury. This is a syndrome marked by excessive release of antidiuretic hormone (ADH or vasopressin) from the posterior pituitary gland or another source.

Diagnosis

Diagnosis include: maintained hypervolemia; suppression of renin-angiotensin system; no equal concentration of atrial natriuretic peptide; low blood urea nitrogen (BUN); low creatinine; low uric acid; and low albumin.

Treatment

Treatment includes fluid restriction , intravenous saline, drugs, and the treatment of underlying causes when possible.

Symptoms and Signs

This syndrome causes dilutional hyponatremia and all the consequences associated with that condition: headache, nausea, vomiting, and confusion may ensue. Severe hyponatremia may result to convulsions or coma.

Causes

Some common causes of SIADH include: head injury, cancers, infections, and drugs.

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