Tolosa-Hunt Syndrome

Below you will find more information about Tolosa-Hunt Syndrome from Medigest. If you believe that you are suffering from any of the symptoms of Tolosa-Hunt Syndrome it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Tolosa-Hunt Syndrome and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Tolosa-Hunt Syndrome comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


Tolosa-Hunt syndrome (THS) is a rare disorder marked by severe and unilateral headaches with extraocular palsies, usually involving the third, fourth, fifth, and sixth cranial nerves, and pain around the sides and back of the eye, along with weakness and paralysis (ophthalmoplegia) of certain eye muscles.


THS is usually diagnosed via exclusion, and as such a vast amount of laboratory tests are needed to rule out other causes of the patients symptoms. These tests include a complete blood count (CBC), thyroid function tests and serum protein electrophoresis.


Treatment of THS is typically completed using corticosteroids (often Prednisone) and immunosupressive agents (such as Methotrexate or Azathioprine). Corticosteroids act as analgesia and lessen pain (usually within 24-72 hours), as well as reducing the inflammatory mass, whereas immunosupressive agents help reduce the autoimmune response.

Symptoms and Signs

Symptoms are usually restricted to one hemisphere of the brain, and in most cases the individual effected will experience intense, sharp pain and paralysis of muscles around the eye.


The exact cause of THS is not known, but the disorder is thought to be, and often assumed to be, linked with inflammation of the areas behind the eyes (cavernous sinus and superior orbital fissure).

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