Wegener’s Granulomatosis

Below you will find more information about Wegener’s Granulomatosis from Medigest. If you believe that you are suffering from any of the symptoms of Wegener’s Granulomatosis it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Wegener’s Granulomatosis and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Wegener’s Granulomatosis comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.

Definition

Wegener's granulomatosis is a form of the vasculitis disorder that primarily affects the lungs, kidneys and other organs. Because it mainly affect the organs, it requires a long term immune suppression (Seo P, Stone JH. The antineutrophil cytoplasmic antibody-associated vasculitides. Am J Med 2004;117:39-50).

Diagnosis

Diagnosis includes blood tests, urine tests for the effect of the disease to the kidneys, biopsy and chest x-ray.

Treatment

Treatment includes administration of corticosteroid especially during the early signs of the disease. Prednisone which is a corticosteroid may be used. Immunosuppresive drug like yclophosphamide like Cytoxan, Imuran which is a azathioprine or Rheumatrex which is methotrexate may be used if the corticosteroid is not enough.

Symptoms and Signs

Its signs and symptoms includes initial signs like protean and presence of Rhinitis and includes the pain in the nose, nosebleeds due to a perforated septum, conductive hearing loss due to auditory tube dysfunction and scleris and conjuctivitis in the eyes. Coin lesions in the lungs and cavitary lesions includign pulmonary hemerrhage causing hemoptysis are also noted.

Causes

Wegener's granulomatosis origin is not that known but it is said to be caused by an infectious agent. Also, it is said that it is a result of an overactive immune system response to an allergic reaction.

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