Whipple Disease

Below you will find more information about Whipple Disease from Medigest. If you believe that you are suffering from any of the symptoms of Whipple Disease it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. There are medical conditions that carry similar symptoms associated with Whipple Disease and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. The information relating to Whipple Disease comes from a third party source and Medigest will not be held liable for any inaccuracies relating to the information shown.


Whipple disease is a systematic and rare disease which is often described as a gastrointestinal disorder that causes mal-absorption and affect other part of the including the heart, lungs, brain and eyes.


Diagnosis and confirmation of the medical condition and disease is made through the use intestinal biopsy, immunohistochemical staining for antibodies against the bacteria Tropheryma whipple and a confirmatory PCR-based assay. Endoscopy and x-ray are also used to confirm the medical condition.


Treatment of Whipple disease includes oral administration and maintenance of penicillin, ampicillin, tetracycline or the co-trimoxazole for at least one to two years.

Symptoms and Signs

Its symptoms includes arthritis, malabsorption, accumulation of fatty deposits in lymph nodes of the intestine, lymphadenopathy, abdominal pain, diarrhea, fever and melanoderma. It may also show pedular vergence oscillations or the eyes and synchronous contractions of the masticatory muscles (Schwartz MA, Selhorst JB, Ochs AL, et al. Oculomasticatory myorhythmia: a unique movement disorder occurring in Whipple's disease. Ann Neurol 1986;20:677-683.[Medline]).


Whipple disease is a disease that is caused by the bacteria Tropheryma whipple (Pu╬śchal X (2002). "Whipple's disease". Joint Bone Spine 69 (2): 133-40).

Discuss Whipple Disease in our forums

Discuss Whipple Disease with other members of Medigest in our forums.